Accessed May 14, 2019. Here are some examples of what squamous cell carcinoma can look like: Your skin has multiple layers. . What does squamous cell carcinoma look like? KASP: keratoacanthomatous atypical squamous proliferation SCC: squamous cell carcinoma STSG: split-thickness skin graft From the Department of Dermatology, Feinberg School of Med-icine, Northwestern University. Disclaimer. When a squamous cell carcinoma is diagnosed, most people are only familiar with the term. Accessed at www.nccn.org/professionals/physician_gls/pdf/squamous.pdf on June 4, 2019. Atypical cells don't necessarily mean you have cancer. Squamous cell skin cancer. Stage 1 Cancer has spread deep into the skin but has not spread to nearby lymph nodes or healthy tissues. MeSH Select data courtesy of the U.S. National Library of Medicine. Wear a hat and cover your skin when working outside. Most cases of cSCC are attributed to exposure to UV radiation from sunlight or indoor tanning equipment like tanning lamps and beds. 8600 Rockville Pike .st3 { DeVita, Hellman, and Rosenbergs Cancer: Principles and Practice of Oncology. The most common abnormal finding in a Pap test is atypical squamous cells with undetermined significance. National Comprehensive Cancer Network (NCCN). Excision: Cutting out the tumor, along with a small margin of normal skin, is often used to treat squamous cell cancers. Squamous cell carcinoma of the skin. Casey Gallagher, MD, is board-certified in dermatology and works as a practicing dermatologist and clinical professor. For reprint requests, please see our Content Usage Policy. Below are some of the resources we provide. Joined: Nov 2009. Seborrheic keratosis and actinic keratosis both cause skin growths, but actinic keratosis may become cancerous. Signet ring cell squamous cell carcinoma. To help reduce your risk of cSCC, follow these tips when possible: Early detection of cSCC is key to successful treatment. Mayo Clinic, Rochester, Minn. June 4, 2019. SCC is the most common malignancy of the conjunctiva in the US, with a yearly incidence of 1-2.8 per 100,000. Arsenic is known to perturb epidermal homeostasis and induce abnormal keratinocyte proliferation, leading to skin carcinogenesis. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Skin cancer types: basal cell carcinoma signs and symptoms. The epidermis has three main types of cells: The cells of the epidermis are constantly shedding to make way for fresh, new skin cells. UV radiation is the most common cause of the DNA mutations that lead to cSCC and other skin cancers. Address correspondence and reprint requests to: Sheldon Sebastian, MD, Dermatology and Skin Cancer Center of Kansas City, Leawood, KS, or e-mail: [email protected] Dermatologic Surgery: March 2011 - Volume 37 - Issue 3 - p 395-398 Tumours are traditionally divided into well, moderately or poorly differentiated tumours by a subjective assessment of how significantly the tumour cells differ from normal keratinocytes. After basal cell carcinoma, squamous cell carcinoma is the second most common variant of skin cancer. information is beneficial, we may combine your email and website usage information with 2005-2023 Healthline Media a Red Ventures Company. Aasi SZ, Hong AM. An official website of the United States government. The main types of skin cancer are: Squamous cells are the cells closest to your skins surface, and their purpose is to line your skin. These cancers usually form on the head, face, neck, hands, and arms, but skin cancer can occur anywhere . Thanks for helping us catch any problems with articles on DeepDyve. If that is the case, you would code for whatever the original biopsy showed. But sun exposure doesn't explain skin cancers that develop on skin not ordinarily exposed to sunlight. privacy practices. These cells are responsible for producing melanin, the pigment that gives skin its color. Squamous cell carcinoma is a malignant tumor arising from epidermal or appendageal keratinocytes or from the squamous mucosal epithelium. See a dermatologist once per year for a full-body skin check. Curettage and electrodesiccation: This approach is sometimes useful in treating small (less than 1 cm across), thin squamous cell cancers, but its not recommended for larger tumors. privacy practices. BCC accounts for some 80% of these cancers, though they rarely cause death. Mohs surgery is a highly successful outpatient procedure used to treat and cure various forms of skin cancers, including basal cell carcinoma. Journal of the American Academy of Dermatology. Her treatment is a reminder of the importance of regular skin, Basal cell carcinoma is the most common and treatable type of skin cancer. clip-path: url(#SVGID_2_); .st1 { But sun exposure doesn't explain skin cancers that develop on skin not ordinarily exposed to sunlight. Squamous cell carcinoma (SCC) is the second most common type of skin cancer,with basal cell carcinoma being the most com-mon. Start a 14-Day Trial for You or Your Team. Atypical squamous cells can be discovered during a routine pap smear. SCC is characterised by proliferation of irregular nests of abnormal squamous cells arising from the epidermis and invading the dermis. Jill Biden and Skin Cancer: What to Know About Risks, Screenings, and Surgery, Basal Cell Carcinoma of the Nose: Types, Identification, and Treatment, keratinocytes (skin cells, also called squamous cells), an open sore that can have raised borders, new growth on an old scar, birthmark, or mole, having light-colored hair and blue, green, or gray eyes, having long-term exposure to UV radiation, living in sunny regions or at a high altitude, having a history of multiple severe sunburns, especially if they occurred early in life, having a history of being exposed to chemicals, such as arsenic. This content does not have an English version. atypical squamous cells, cannot exclude high grade squamous intraepithelial lesion (asc-h) atrophic pattern; predominantly parabasal cells? You can find out more about our use, change your default settings, and withdraw your consent at any time with effect for the future by visiting Cookies Settings, which can also be found in the footer of the site. Summary. Mayo Clinic does not endorse companies or products. } Mohs Surgery for Squamous Cell Skin Cancer For squamous cell carcinomas, Mohs surgery has the highest cure rate of all treatments. Careers. Alam M, et al. American Academy of Dermatology Association. Mayo Clinic is a not-for-profit organization. Keratoacanthoma is a common type of squamous cell cancer. journals.lww.com/dermatologicsurgery/Fulltext/2015/04000/Family_History_of_Skin_Cancer_Is_Associated_With.7.aspx, cancer.org/cancer/basal-and-squamous-cell-skin-cancer/causes-risks-prevention/risk-factors.html, cancer.gov/about-cancer/treatment/drugs/skin, cancer.gov/types/skin/hp/skin-genetics-pdq, cancer.gov/types/lung/hp/non-small-cell-lung-treatment-pdq, skincancer.org/skin-cancer-information/skin-cancer-facts/, aad.org/public/diseases/skin-cancer/types/common/scc/symptoms, aad.org/public/diseases/skin-cancer/types/common, mskcc.org/cancer-care/types/mouth/types-mouth, cancer.org/cancer/basal-and-squamous-cell-skin-cancer/about/what-is-basal-and-squamous-cell.html, Prognosis and Outlook for Stage 4 Squamous Cell Carcinoma, Carcinoma Types: Squamous Cell, Basal Cell, Transitional Cell, and More, Survival Rates for Different Types of Skin Cancer, What You Need to Know About Skin Cancer on the Scalp, Everything You Need to Know About Nonmelanoma Skin Cancer, Mohs Surgery for Basal Cell Carcinoma: Before and After Treatment. Christensen SR, Wilson LD, Leffell DJ. You can see your Bookmarks on your DeepDyve Library. View. Here's how to tell them apart. Atypical squamous proliferation: what lies beneath? LGA Airport Airline Terminals Map Airline Terminal Frontier Airlines Departure: C- Arrivals: D JetBlue Departure: A- Arrivals: A Southwest Airlines Departure: B Arrivals: B, Its mostly a preference, but having two save files where you saved Park and another where you saved Lazar doesnt hurt. Abstract Background Dermatosis is a general term for diseases of the skin and skin appendages including scleroderma, psoriasis, bullous disease, atopic dermatitis, basal cell carcinoma, squamous ce. Another type of skin cancer, melanoma, is more dangerous but less common. These skin cells also cause normal moles to form. It also discusses the link to sun exposure and why this type of cancer is on the rise as people age. Also called atypical melanocytic proliferation or benign atypical junctional melanocytic hyperplasia Case reports. Practice Guidelines in Oncology: Squamous Cell Skin Cancer. information and will only use or disclose that information as set forth in our notice of Atypical cells can change back to normal cells if the underlying cause is removed or resolved. North Carolina. Cervical cysts or polyps. These abnormal growths can develop anywhere, but theyre most often found in areas that receive the most exposure to ultraviolet (UV) radiation, either from sunlight or from tanning beds or lamps. With the help of mirrors, check your face, neck, ears and scalp. Different types of surgery can be used to treat squamous cell skin cancers. Journal of the American Academy of Dermatology. Our surgeons may need to remove more tissue if we have squamous cell cancer, which can be aggressive. Require these words, in this exact order. Basal cells sit below the squamous cells, and theyre constantly dividing to form new cells. What Are the Different Types of Skin Cancer? Cover your skin with dark, tightly woven clothing that covers your arms and legs, and a broad-brimmed hat, which provides more protection than does a baseball cap or visor. Cells become damaged for many reasons, and the progression of that damage from normal to malignant is a cascade . 2018;78:560. Chemotherapy and sex: Is sexual activity OK during treatment? Nonmelanoma skin cancers form in the outer layers of your skin. Is atypical squamous proliferation malignant? https://www.nccn.org/professionals/physician_gls/default.aspx. 16 By contrast with normal nonsunexposed skin, distinct positive p53 staining was found in the basal cell layer of molluscum contagiosum. Basal cell carcinoma. Ashley G. Rubin. Search and discover articles on DeepDyve, PubMed, and Google Scholar, Organize articles with folders and bookmarks, Collaborate on and share articles and folders. clip-path: url(#SVGID_6_); Your doctor will first perform a physical exam and inspect any abnormal areas for signs of cSCC. High-risk tumors, on the other hand, have a less favorable prognosis, with a risk of metastasis of up to 48%. Find any of these words, separated by spaces, Exclude each of these words, separated by spaces, Search for these terms only in the title of an article, Most effective as: LastName, First Name or Lastname, FN, Search for articles published in journals where these words are in the journal name, /lp/wiley/atypical-squamous-proliferation-what-lies-beneath-YyR97Kh0xd, Clinical significance of cytologic atypical squamous cells of undetermined significance, The value of preoperative biopsysite photography for identifying cutaneous lesions, Gene expression patterns of normal human skin, actinic keratosis, and squamous cell carcinoma, Cutaneous collision tumors. include protected health information. Cryosurgery. } Such cells can be found during pregnancy, early menopause, and in women or men who are receiving hormonal therapy (androgen deprivation for prostate cancer) at a young age. In the past few years there has been an increase in the . The abnormal cells in the tissue that line the outer part of the cervix have been discovered. Can a Pap smear detect atypical squamous cells? Mayo Clinic does not endorse companies or products. Its the second most common type of skin cancer. https://www.cancer.gov/types/cervical/pap-hpv-testing-fact-sheet. Squamous cells can be found in a variety of locations throughout the body. You will also This can make cosmetics applications easier, save you money on other products, and provide a more youthful appearance. How to get nutrition during cancer treatment, Infographic: Scalp Cooling Therapy for Cancer, Stem cells: What they are and what they do, Thalidomide: Research advances in cancer and other conditions, TVEC (Talimogene laherparepvec) injection, When cancer returns: How to cope with cancer recurrence, Advertising and sponsorship opportunities. 64 year old woman with esophageal squamous cell carcinoma in situ (Virchows Arch 2000;437:203) Microscopic (histologic) description . Atypical squamous proliferation: what lies beneath? https://www.cancer.gov/types/cervical/understanding-cervical-changes. In this study we investigated the number of blood vessels and vascular proliferation in subepithelial areas of 80 cervical condylomas and cervical intraepithelial . Systemic chemotherapy and/or targeted therapy: Chemotherapy and targeted therapy drugs (EGFR inhibitors) might be other options for patients with squamous cell cancer that has spread to lymph nodes or distant organs. Variable keratinisation ( keratin pearls etc) is present (figure 2). Is moderately differentiated squamous cell carcinoma also curable? Although this seems like a prudent approach, scientific evidence for this is . Background: The current standards of treatment for oral squamous cell carcinoma (OSCC) include surgery, radiotherapy, and chemotherapy. Connect with others like you for support and answers to your questions in the Cancer support group on Mayo Clinic Connect, a patient community. Atypical squamous cells can be a sign of: HPV (human papillomavirus) infection. People also inquire as to what constitutes squamous proliferation. Choquet H, Ashrafzadeh S, Kim Y, Asgari MM, Jorgenson E. Genetic and environmental factors underlying keratinocyte carcinoma risk. This content does not have an Arabic version. Squamous cell carcinoma of the skin care at Mayo Clinic. Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. It is considered a precancerous dermatosis, in the same group as leukoplakia, senile keratosis, and xeroderma pigmentosum. Atrophy is a term used to describe a shrinkage of prostate tissue (when it is seen under the microscope). 2019;25(8):2379-2391. doi: 10.1158/1078-0432.CCR-18-1122. However, these drugs havent been studied in people with weakened immune systems, such as people who take medicines for autoimmune diseases or who have had an organ transplant, so the balance between benefits and risks for these people isnt clear. Squamous Cell skin cancer can develop as a result of abnormal growth of squamous cells caused by Squamous Cell Carcinoma or warts. Check your skin regularly and report changes to your doctor. Skin tags are common, noncancerous skin growths. Most BCCs are linked to long-term exposure to and damage from ultraviolet (UV) radiation. The https:// ensures that you are connecting to the (2019). Clin Cancer Res. Examine your skin often for new skin growths or changes in existing moles, freckles, bumps and birthmarks. In: DeVita VT, Lawrence TS, Rosenberg SA, eds. That is why it is important to be aware of these moles, get them checked by your dermatologist, and watch out for changing moles. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. They can also be found in the skins middle layers. Cutaneous SCC (cSCC) is a cancer that develops in the squamous cells of your skin. CCN1 regulates the proliferation of abnormal keratinocytes whereas CCN2 regulates tumor . 2018 May;80(2):303-317. doi:10.1016/j.jaad.2018.03.060, Iannacone MR, Wang W, Stockwell HG, et al. The process of creating new skin cells is controlled by a basal cell's DNA. Make a donation. Findings of atypical hyperplasia account for 10% of benign . Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. They are also seen in the middle layers of the skin. Squamous cells are also found in other parts of your body such as your lungs, mucous membranes, digestive tract, and urinary tract. A Study Says UV Nail Dryers May Pose Skin Cancer Risks. Please enable it to take advantage of the complete set of features! information highlighted below and resubmit the form. If we combine this information with your protected . Signet ring cell squamous cell carcinoma. Different types of cancer start in the skin. Sun safety. When treatment isnt received quickly, the growths can increase in size and spread to other parts of your body, causing serious complications. Squamous cell carcinoma of the skin with signet ring cell morphology is very rare. These abnormal cell collections are benign (not cancer), but are high-risk for cancer. information and will only use or disclose that information as set forth in our notice of Cryosurgery. Cancer.org is provided courtesy of the Leo and Gloria Rosen family. Methods: Cytological characteristics were evaluated in 432 patients who underwent lymph node FNAC and follow-up biopsy at the Korea Cancer Center Hospital from January 2015 to . In some cases, your doctor may need to remove a larger part or all of the abnormal growth for testing. The .gov means its official. You may opt-out of email communications at any time by clicking on The other 20% are cSCC. }. (Also known as/Synonyms) Ackerman's Tumor Cutaneous Verrucous Squamous Cell Carcinoma Enjoy Smoother Skin. Non-Small Cell Lung Cancer Treatment (PDQ®)Health Professional Version. Its a good idea to see a doctor right away if you suspect you have any type of skin cancer. OP. Semin Diagn Pathol 1993 May;10 (2):148-58. National Cancer Institute. However, it's still important to make sure there's no cancer present or that a cancer isn't just starting to develop. To protect yourself: Wear protective clothing. Family history of skin cancer is associated with increased risk of cutaneous squamous cell carcinoma. WLE cures low-risk tumors and reduces the risk of nodal metastasis. Metastatic disease is uncommon. 4 The . Anyone can get skin cancer, but it is more common in people who : SCC presents as an irregular keratinous nodule or a firm erythematous plaque, and frequently ulcerates. Signs and symptoms of squamous cell carcinoma of the skin include: Make an appointment with your doctor if you have a sore or scab that doesn't heal in about two months or a flat patch of scaly skin that won't go away. Cutaneous squamous cell carcinoma accounts for just one of every five cases but it is the more dangerous of the two. But it's also possible for their cell division to go awry, leading to what are sometimes called "keratinocyte cancers." Histologically, Bowen disease presents as intraepithelial atypia, with marked variation in cell and nuclear size . Treatments may include: Some doctors may also use laser surgery and topical medications to treat cSCC. If you are a Mayo Clinic patient, this could Search Though cSCC occurs less often, it may have more serious outcomes, including death. If you dont receive our email within 5 minutes, check your SPAM folder, then contact us Cutaneous squamous cell carcinoma is most common, but it can spread to other parts of the body. . Disclosure: Dr Guitart has been a consultant for DermTech International and Seattle Genetics Inc. Dr Gerami has . What does it take to outsmart cancer? If cSCC is suspected, your doctor may decide to take a biopsy to confirm the diagnosis. It's important to be aware of these moles, because they can turn into melanomas. 2023 American Cancer Society, Inc. All rights reserved. Facial Plast Surg Clin North Am. Diagnosis confirmation Once advanced squamous cell carcinoma has spread to the lymph nodes and beyond, the survival rates are lower. sheldon.sebastian@gmail.com; PMID: 21342317 DOI: 10.1111/j.1524-4725.2011.01895.x No abstract available. A pap smear scrapes cells from the cervix to check for abnormal growth. (2021). And sometimes, your doctor may need to obtain a sample of tissue such as a biopsy to make sure you don't have cancer or another serious condition. Sign up today, get DeepDyve free for 14 days. Mayo Clinic does not endorse any of the third party products and services advertised. Although cSCC isnt life threatening, it can become dangerous if it goes untreated. Most of the DNA mutations in skin cells are caused by ultraviolet (UV) radiation found in sunlight and in commercial tanning lamps and tanning beds. Skin cancer is the most common form of cancer in the United States. Squamous Cell skin cancer can develop as a result of abnormal growth of squamous cells caused by Squamous Cell Carcinoma or warts. Guidelines of care for the management of cutaneous squamous cell carcinoma. In: Clinical Dermatology: A Color Guide to Diagnosis and Therapy. Nonmelanoma skin cancers: Basal cell and squamous cell carcinomas. : Saunders Elsevier; 2016. https://www.clinicalkey.com. The skin sample is then sent to a laboratory for testing. Anyone, regardless of skin color, can get squamous cell carcinoma of the skin. Accessed at https://www.uptodate.com/contents/systemic-treatment-of-advanced-cutaneous-squamous-and-basal-cell-carcinomas on June 4, 2019. . As a result, these specimens are often signed out as atypical squamous proliferations (ASPs). Squamous epithelial cells are a type of flat cell found throughout the body, including in the mouth, on the lips, and on the cervix. See pictures and learn about causes, prevention, diagnosis, treatment, and, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. Bhanusivakumar RS, et al. Skin cancer begins in the cells that make up the outer layer (epidermis) of your skin. It's thought that early exposure to UV light, in childhood and youth, contributes to the development of BCC and cSCC. time. The changes are almost always indicative of an HPV infection. As a stand-along diagnosis, I would code "atypical melanocytic proliferation" or "melanocytic proliferation" D48.5 (neoplasm of uncertain behavior). 2018 Feb;30(2):238. doi:10.5021/ad.2018.30.2.238, Kim JYS, Kozlow JH, Mittal B, et al. According to the American Academy of Dermatology, cSCC is most commonly red or pink. Start a 14-Day Trial for You or Your Team. However, if basal cell cancer goes untreated, it can eventually spread to your bones and other tissues. When atrophy only affects certain areas of the prostate, it is called focal atrophy. Philadelphia, Pa: Lippincott Williams & Wilkins; 2019. D23.9 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. Atypical moles (known in medical terms as dysplastic nevi) are similar to common moles in that melanoma usually does not develop in either. Although rare, melanoma can arise in association with atypical moles. The authors have indicated no significant interest with commercial supporters. Treating Basal and Squamous Cell Skin Cancer, About Basal and Squamous Cell Skin Cancer, Making Strides Against Breast Cancer Walks, ACS Center for Diversity in Research Training, Surgery for Basal and Squamous Cell Skin Cancers, Local Treatments Other than Surgery for Basal and Squamous Cell Skin Cancers, Radiation Therapy for Basal and Squamous Cell Skin Cancers, Systemic Chemotherapy for Basal and Squamous Cell Skin Cancers, Targeted Therapy for Basal and Squamous Cell Skin Cancers, Immunotherapy for Advanced Basal or Squamous Cell Skin Cancers, Treating Squamous Cell Carcinoma of the Skin, Treating Actinic Keratosis and Bowen Disease. Many factors can make normal cells appear atypical, including inflammation and infection. Additional Info These patients were treated at Shanghai Skin Diseases Hospital or Ren Ji Hospital between 2011 and 2015. Howell JY, et al. Guidelines of care for the management of cutaneous squamous cell carcinoma. Here you'll find in-depth information on specific cancer types including risk factors, early detection, diagnosis, and treatment options. Other potential causes include: Treatment for cSCC varies. Immunotherapy: For advanced squamous cell cancers that cant be cured with surgery or radiation therapy, one option might be using an immunotherapy drug such as cemiplimab (Libtayo) or pembrolizumab (Keytruda). An analysis of 69 cases and review of the literature. What does this mean? Problems in the current TNM staging of nonmelanoma skin cancer of the head and neck. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. National Cancer Institute. 6th ed. They were placed on your computer when you launched this website. Member. ErrorSelect Member. AREG transgenic animals show epidermal acanthosis, keratinocyte hyperproliferation, hyperkeratosis, cutaneous immune cell infiltration and angiogenesis in the skin ( 16 , 17 ). What are basal and squamous cell skin cancers? Basal and squamous cell skin cancer risk factors. After BCC, cutaneous squamous cell carcinoma (cSCC) is the second most common kind of skin cancer. Untreated, squamous cell carcinoma of the skin can grow large or spread to other parts of your body, causing serious complications. An early diagnosis and treatment are critical for preventing complications. All rights reserved. Treatment options for squamous cell skin cancer depend on the risk of the cancer coming back, which is based on factors like the size and location of the tumor and how the cancer cells look under a microscope, as well as if a person has a weakened immune system. High-dose vitamin C: Can it kill cancer cells? For squamous cell carcinomas, Mohs surgery has the highest cure rate of all treatments. 6th ed. The removed lymph nodes are looked at under a microscope to see if they contain cancer cells. 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Keep reading to learn more about this type of skin cancer, what it looks like, what causes it, and how its diagnosed and treated. An atypical mole may also be referred to as an atypical melanocytic . In: Niederhuber JE, Armitage JO, Doroshow JH, Kastan MB, Tepper JE, eds. Mohs Surgery for Squamous Cell Skin Cancer. If you've recently received abnormal Pap smear results involving the presence of atypical squamous cells, call 1-888-663-3488 or submit a new patient registration form online to request an appointment with one of Moffitt's gynecologic oncologists. The increased proliferative activity of endothelial cells in CIN IIIII lesions suggests that they are angiogenically more active than condylomas and CIN I lesions, which does not, however, depend on the HPV or p53 status. The tumor typically appears as a papule or nodule, Multiple self-healing squamous epithelioma (MSSE), also known as Ferguson-Smith disease, is a rare inherited cancer that can heal itself on its own. Squamous cell carcinoma is a life-threatening type of skin cancer. A much smaller number occur on the torso and legs. other information we have about you. Philadelphia, Pa: Elsevier; 2020. 2019. In rare cases, squamous cell cancers can spread to lymph nodes or distant parts of the body. An important question raised by our results is the functional status of the p53 . Its also important to follow recommended screening guidelines, which can help detect certain cancers early. But it can occur anywhere on your body, including inside your mouth, the bottoms of your feet and on your genitals. Its a rapidly growing tumor that appears out of nowhere and can grow to a large size. SEBASTIAN, SHELDON; YANKO, RAVIT; GOLDSTEIN, GLENN D. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png, http://www.deepdyve.com/lp/wolters-kluwer-health/atypical-squamous-proliferation-what-lies-beneath-YyR97Kh0xd. You may opt-out of email communications at any time by clicking on "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. EXCISION - numb the area with local anesthesia, remove skin cancer or atypical mole and stitch it closed. Be sure to tell your healthcare provider if you have a personal history or family history of skin cancer. People with weakened immune systems due to certain medical conditions, such as HIV, AIDS, or leukemia, have a greater risk of developing more serious forms of cSCC.