Taking promethazine / codeine with benzodiazepines or alcohol can cause you to be extremely sleepy. Respiratory symptoms caused by allergies or the common cold, including cough, runny nose, and sneezing. Drug Mild, uncomplicated allergic skin manifestations of urticaria and angioedema. larry carter obituary 2021 Hallucinations have also been reported. Promethazine HCl may be used alone or as an adjunct to narcotic analgesics during labor (see DOSAGE AND ADMINISTRATION).
CAUTION SHOULD BE EXERCISED WHEN ADMINISTERING PROMETHAZINE HYDROCHLORIDE TO PEDIATRIC PATIENTS 2 YEARS OF AGE AND OLDER. It has a molecular weight of 320.88, a molecular formula of C17H20N2SHCI, and the following structural formula: Phenylephrine hydrochloride is a sympathomimetic amine salt which is chemically designated as (-)-m-Hydroxy--[(methylamino)methyl] benzyl alcohol hydrochloride.
Hallucinations have also been reported.
Codeine is an opioid medication that works in your brain to lessen your urge to cough. (See WARNINGS-Neuroleptic Malignant Syndrome.).
Promethazine HCl Oral Solution should be used with caution in patients with bone-marrow depression.
Manufacturers of Promethazine Hydrochloride that have been granted an NDC (National Drug Code). The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. All rights reserved. 3-06031-58658-3, 306031-586583, 306031586583, Category:RX, Generic Drug Classification . Trade Name : Promethazine with Codeine Par Pharmaceutical SOLUTION 6.25 10 mg/5mL mg/5mL Storage and handling for Promethazine with Codeine PROMETHAZINE HYDROCHLORIDE; CODEINE PHOSPHATE Phenothiazine [EPC],Phenothiazines [CS],Full Opioid Agonists [MoA],Opioid Agonist [EPC] Disclaimer
Be sure to use a medication dose cup, spoon, or syringe to measure out your dose. These are the cells that fight off infections, and without the right amount, you can get sick easier and have a harder time getting better. Antihistamines are contraindicated for use in the treatment of lower respiratory tract symptoms including asthma. Gabapentin is a controlled substance in states like Michigan and Kentucky, while others have mandated reporting rules.
Store at 20 to 25C (68 to 77F) [see USP Controlled Room Temperature]. Teratogenic effects have not been demonstrated in rat-feeding studies at doses of 6.25 and 12.5 mg/kg of promethazine HCl. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. It is important that Promethazine HCl Oral Solution is measured with an accurate measuring device (see PRECAUTIONS-Information for Patients). 12.5- to 25-mg doses may be repeated, as necessary, at 4- to 6-hour intervals. Usual adult dosage is 50 mg Promethazine with an appropriately reduced dose of narcotic or barbiturate and the required amount of a belladonna alkaloid. Phenylephrine should be used with caution in patients with cardiovascular disease, particularly hypertension. It is not known whether this drug combination can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Drugs having anticholinergic properties should be used with caution in patients with narrow-angle glaucoma, prostatic hypertrophy, stenosing peptic ulcer, pyloroduodenal obstruction, and bladder-neck obstruction. It is not known whether Promethazine HCl is excreted in human milk. Promethazine is an antihistamine. Learn about its risk for abuse here. Promethazine and phenylephrine hydrochloride oral solutionshould be used with caution in pediatric patients 2 years of age and older (see WARNINGS Use In Pediatric Patients). All rights reserved.
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Available for Android and iOS devices. By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx. Par Pharmaceutical, a wholly owned Endo business, is a highly focused generic pharmaceutical company dedicated to delivering quality medicines to patients in need through excellence in innovation, development, manufacturing, and commercialization. Like other opioid-containing medications, promethazine / codeine has a potential for abuse, misuse, or addiction, which can lead to complications such as overdose and death. Drug facts, warnings, and ingredients follow. and untreated or inadequately treated extrapyramidal signs and symptoms (EPS). If you've ever had seizures or if you have seizures conditions like epilepsy, taking promethazine / codeine can cause you to have seizures more often. Specify your dosage and quantity to find out exactly how much you can save. Children 6 To Under 12 Years Of Age These doses are from approximately 2.1 to 4.2 times the maximum recommended total daily dose of promethazine for a 50-kg subject, depending upon the indication for which the drug is prescribed. Risk factors: Taking promethazine / codeine at the same time as benzodiazepines or alcohol. Diazepam may be used to control convulsions.
Drug Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate, Losartan Potassium and Hydrochlorothiazide, Oxycodone Hydrochloride and Acetaminophen, NPI Look-Up Tool (National Provider Identifier), Generics Bidco I, LLC dba Qualitest Pharmaceuticals. Alcohol 7%.
Hallucinations and convulsions have occurred with therapeutic doses and overdoses of promethazine hydrochloride in pediatric patients. This can cause you to pass out or fall. Attention should be given to the reestablishment of adequate respiratory exchange through provision of a patent airway and institution of assisted or controlled ventilation. Excessively large dosages of antihistamines, including promethazine hydrochloride, in pediatric patients may cause sudden death (see OVERDOSAGE). Like all opioids, codeine can be habit-forming, although the risk with this medication is low. A study in rabbits indicated that continued moderate overexposure to phenylephrine (3 mg/day) during the second half of pregnancy (22nd day of gestation to delivery) may contribute to perinatal wastage, prematurity, premature labor, and possibly fetal anomalies; when phenylephrine (3 mg/day) was given to rabbits during the first half of pregnancy (3rd day after mating for seven days), a significant number gave birth to litters of low birth weight. Because phenylephrine is an adrenergic agent, it should be given with caution to patients with thyroid diseases, diabetes mellitus, and heart disease or those receiving tricyclic antidepressants. People who take either typical or atypical antipsychotic medications have a higher risk of this happening. Signs and symptoms of overdosage with phenylephrine include hypertension, headache, convulsions, cerebral hemorrhage, and vomiting. Epinephrine Because of the potential for promethazine to reverse epinephrine's vasopressor effect, epinephrine should NOT be used to treat hypotension associated with promethazine overdose. CONCOMITANT ADMINISTRATION OF PROMETHAZINE PRODUCTS WITH OTHER RESPIRATORY DEPRESSANTS HAS AN ASSOCIATION WITH RESPIRATORY DEPRESSION, AND SOMETIMES DEATH, IN PEDIATRIC PATIENTS. Taking promethazine / codeine with food can help lessen or prevent stomach-related side effects like nausea. Perennial and seasonal allergic rhinitis. Gastrointestinal Dry mouth, nausea, vomiting, jaundice. Administration of 12.5 to 25 mg Promethazine by the oral route will provide sedation in children. Pregnancy Tests:Diagnostic pregnancy tests based on immunological reactions between HCG and anti-HCG may result in false-negative or false-positive interpretations.
(See WARNINGS Promethazine; Neuroleptic Malignant Syndrome.). Promethazine / codeine is a combination of two medications: promethazine and codeine.
Codeine is an opioid medication that works in your brain to lessen your urge to cough. Avoid activities that require you to be alert (like driving) until you know how it affects you. It is thought that this configuration is responsible for its relative lack (1/10 that of chlorpromazine) of dopamine antagonist properties. Promethazine HCl Oral Solution may cause marked drowsiness or impair the mental and/or physical abilities required for the performance of potentially hazardous tasks, such as driving a vehicle or operating machinery.
No, they shouldn't.
The following side effects may get better over time as your body gets used to the medication. After initiation of treatment in children or adults, dosage should be adjusted to the smallest amount adequate to relieve symptoms. (See also Nonteratogenic Effects.). Promethazine: Promethazine HCl Oral Solution should be used cautiously in persons with cardiovascular disease or with impairment of liver function. EPINEPHRINE SHOULD NOT BE USED, since its use in patients with partial adrenergic blockade may further lower the blood pressure. Can I drink alcohol while using promethazine / codeine? The concomitant use of alcohol or other central nervous system depressants, including narcotic analgesics, sedatives, hypnotics, and tranquilizers, may have an additive effect and should be avoided or their dosage reduced. Promethazine HCl Oral Solution is contraindicated for use in pediatric patients less than two years of age. Par Pharmaceutical, a wholly owned Endo business, is a highly focused generic pharmaceutical company dedicated to delivering quality medicines to patients in need through excellence in innovation, development, manufacturing, and commercialization. Without the right amount of these hormones, your body can't fight off infections properly.
Promethazine / codeine can cause your blood pressure to drop to extremely low levels. Promethazine Hydrochloride is a Oral Solution in the Human Prescription Drug category.
We have already encountered some chemical formulas for simple ionic compounds. Phenylephrine with atropine sulfate. Daily doses of 25 mg/kg intraperitoneally have been found to produce fetal mortality in rats.
Phenylephrine is a potent postsynaptic -receptor agonist with little effect on -receptors of the heart. Specific studies to test the action of the drug on parturition, lactation, and development of the animal neonate were not done, but a general preliminary study in rats indicated no effect on these parameters. Postmarketing cases of respiratory depression, including fatalities, have been reported with use of Promethazine in pediatric patients less than 2 years of age. Caution should be exercised when administering Promethazine HCl Oral Solution to pediatric patients 2 years of age and older because of the potential for fatal respiratory depression. Long-term use of promethazine / codeine can cause dependence. Sedation, somnolence, blurred vision, dizziness; confusion, disorientation, and extrapyramidal symptoms such as oculogyric crisis, torticollis, and tongue protrusion; lassitude, tinnitus, incoordination, fatigue, euphoria, nervousness, diplopia, insomnia, tremors, convulsive seizures, excitation, catatonic-like states, hysteria. This side effect is rare but can be life-threatening. Therapy adjunctive to meperidine or other analgesics for control of post-operative pain. Activated charcoal orally or by lavage may be given, or sodium or magnesium sulfate orally as a cathartic. Respiratory Depression Promethazine may lead to potentially fatal respiratory depression. Clinical studies of promethazine and phenylephrine hydrochloride oral solutiondid not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects.
Codeine is an opioid (narcotic) cough suppressant. Active and prophylactic treatment of motion sickness. Promethazine / codeine is an inexpensive cough syrup that can help calm coughs and nasal symptoms caused by respiratory infections or allergies, but it should only be used for a short period of time as it can be habit-forming. Product ID: 0603-1584_153678e2-0b91-4267-a9b9-e0a9913a98a3: NDC: 0603-1584: Product Type: Along with its needed effects, a medicine may cause some unwanted effects.
Promethazine with Codeine Oral Solution is a federal controlled substance (C-V) because it contains codeine that can be abused or lead to dependence.
These side effects are more intense if you are over 65 years old. Phenylephrine: If you are having difficulty accessing this website, please call or email us at (855) 268-2822 or ada@goodrx.com so that we can provide you with the services you require through alternative means. Promethazine is a phenothiazine medication that blocks the signals in your brain and body causing you to experience cold and allergy symptoms like a runny nose and sneezing.
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That works in your brain to lessen your urge to cough Solution should be EXERCISED when ADMINISTERING Promethazine Hydrochloride have! Patent airway and institution of assisted or controlled ventilation reporting rules is an opioid medication works...The effect on later growth and development of the newborn is unknown. Administration of Promethazine HCl has been associated with reported cholestatic jaundice. People who have breathing problems such as chronic obstructive pulmonary disease (COPD), sleep apnea, asthma, or are taking other medications that can affect breathing (opioids, sleeping medications) also have a higher risk of this problem. Respiratory depression and apnea, sometimes associated with death, are strongly associated with Promethazine products and are not directly related to individualized weight-based dosing, which might otherwise permit safe administration.